Effects of Mindfulness-Based Stress Reduction on Psychological Symptoms and Telomere Length: A Randomized Active-Controlled Trial.
Identifieur interne : 000307 ( Main/Exploration ); précédent : 000306; suivant : 000308Effects of Mindfulness-Based Stress Reduction on Psychological Symptoms and Telomere Length: A Randomized Active-Controlled Trial.
Auteurs : Shian-Ling Keng [Singapour] ; Pei Shan Looi [Singapour] ; Elysia Li Yan Tan [Singapour] ; Onn-Siong Yim [Singapour] ; Poh San Lai [Singapour] ; Soo Hong Chew [Singapour] ; Richard P. Ebstein [République populaire de Chine]Source :
- Behavior therapy [ 1878-1888 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- génétique : Stress psychologique, Troubles anxieux.
- thérapie : Stress psychologique, Troubles anxieux.
- Adulte, Anxiété, Humains, Pleine conscience, Résultat thérapeutique, Télomère.
English descriptors
- KwdEn :
- MESH :
- genetics : Anxiety Disorders, Stress, Psychological.
- therapy : Anxiety Disorders, Stress, Psychological.
- Adult, Anxiety, Humans, Mindfulness, Telomere, Treatment Outcome.
Abstract
Much research has demonstrated the beneficial effects of mindfulness-based stress reduction (MBSR) on psychological and physical health, but it is not known whether MBSR may impact cellular aging in healthy populations. Further, little research has evaluated MBSR against an active control condition, which precludes strong conclusions regarding the unique effects of mindfulness on psychological functioning. The present study examined the effects of MBSR versus music therapy-based stress reduction (MTSR) on trait mindfulness, self-compassion, and several psychological health outcomes, as well as leukocyte telomere length (LTL). One hundred and fifty eight Singaporean Chinese adults were recruited and randomly assigned to an eight-week MBSR or MTSR course. Participants provided blood samples and completed a battery of self-report measures pre- and post-intervention. Analyses showed that participants in the MBSR condition demonstrated significantly greater improvements in depressive symptoms, trait mindfulness, and self-compassion compared to the control condition. Treatment condition did not predict changes in LTL, anxiety, stress, or happiness, though there was a trend for duration of home mindfulness practice to predict increases in LTL. Overall, the study demonstrated MBSR's unique effects in reducing depressive symptoms. Improvements in trait mindfulness and self-compassion correspond with theorized mechanisms of change underlying mindfulness training. The lack of intervention effect with regards to LTL suggests that a more intensive intervention may be required for mindfulness to exert noticeable impact on aging at the cellular level, or that the effect may only emerge over a longer term.
DOI: 10.1016/j.beth.2020.01.005
PubMed: 33051039
Affiliations:
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Electronic address: kengsl@yale-nus.edu.sg.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Yale-NUS College</wicri:regionArea></affiliation></author><author><name sortKey="Looi, Pei Shan" sort="Looi, Pei Shan" uniqKey="Looi P" first="Pei Shan" last="Looi">Pei Shan Looi</name><affiliation wicri:level="1"><nlm:affiliation>National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Elysia Li Yan" sort="Tan, Elysia Li Yan" uniqKey="Tan E" first="Elysia Li Yan" last="Tan">Elysia Li Yan Tan</name><affiliation wicri:level="1"><nlm:affiliation>National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Yim, Onn Siong" sort="Yim, Onn Siong" uniqKey="Yim O" first="Onn-Siong" last="Yim">Onn-Siong Yim</name><affiliation wicri:level="1"><nlm:affiliation>National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Lai, Poh San" sort="Lai, Poh San" uniqKey="Lai P" first="Poh San" last="Lai">Poh San Lai</name><affiliation wicri:level="1"><nlm:affiliation>National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Chew, Soo Hong" sort="Chew, Soo Hong" uniqKey="Chew S" first="Soo Hong" last="Chew">Soo Hong Chew</name><affiliation wicri:level="1"><nlm:affiliation>National University of Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>National University of Singapore</wicri:regionArea></affiliation></author><author><name sortKey="Ebstein, Richard P" sort="Ebstein, Richard P" uniqKey="Ebstein R" first="Richard P" last="Ebstein">Richard P. Ebstein</name><affiliation wicri:level="1"><nlm:affiliation>China Center for Behavior Economics and Finance, South Western University of Finance and Economics, China. Electronic address: rpebstein@gmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>China Center for Behavior Economics and Finance, South Western University of Finance and Economics</wicri:regionArea><wicri:noRegion>South Western University of Finance and Economics</wicri:noRegion></affiliation></author></analytic><series><title level="j">Behavior therapy</title><idno type="eISSN">1878-1888</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Anxiety (MeSH)</term><term>Anxiety Disorders (genetics)</term><term>Anxiety Disorders (therapy)</term><term>Humans (MeSH)</term><term>Mindfulness (MeSH)</term><term>Stress, Psychological (genetics)</term><term>Stress, Psychological (therapy)</term><term>Telomere (MeSH)</term><term>Treatment Outcome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Anxiété (MeSH)</term><term>Humains (MeSH)</term><term>Pleine conscience (MeSH)</term><term>Résultat thérapeutique (MeSH)</term><term>Stress psychologique (génétique)</term><term>Stress psychologique (thérapie)</term><term>Troubles anxieux (génétique)</term><term>Troubles anxieux (thérapie)</term><term>Télomère (MeSH)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Anxiety Disorders</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Stress psychologique</term><term>Troubles anxieux</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Anxiety Disorders</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Stress psychologique</term><term>Troubles anxieux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Anxiety</term><term>Humans</term><term>Mindfulness</term><term>Telomere</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Anxiété</term><term>Humains</term><term>Pleine conscience</term><term>Résultat thérapeutique</term><term>Télomère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Much research has demonstrated the beneficial effects of mindfulness-based stress reduction (MBSR) on psychological and physical health, but it is not known whether MBSR may impact cellular aging in healthy populations. Further, little research has evaluated MBSR against an active control condition, which precludes strong conclusions regarding the unique effects of mindfulness on psychological functioning. The present study examined the effects of MBSR versus music therapy-based stress reduction (MTSR) on trait mindfulness, self-compassion, and several psychological health outcomes, as well as leukocyte telomere length (LTL). One hundred and fifty eight Singaporean Chinese adults were recruited and randomly assigned to an eight-week MBSR or MTSR course. Participants provided blood samples and completed a battery of self-report measures pre- and post-intervention. Analyses showed that participants in the MBSR condition demonstrated significantly greater improvements in depressive symptoms, trait mindfulness, and self-compassion compared to the control condition. Treatment condition did not predict changes in LTL, anxiety, stress, or happiness, though there was a trend for duration of home mindfulness practice to predict increases in LTL. Overall, the study demonstrated MBSR's unique effects in reducing depressive symptoms. Improvements in trait mindfulness and self-compassion correspond with theorized mechanisms of change underlying mindfulness training. The lack of intervention effect with regards to LTL suggests that a more intensive intervention may be required for mindfulness to exert noticeable impact on aging at the cellular level, or that the effect may only emerge over a longer term.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">33051039</PMID><DateCompleted><Year>2021</Year><Month>02</Month><Day>04</Day></DateCompleted><DateRevised><Year>2021</Year><Month>02</Month><Day>04</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-1888</ISSN><JournalIssue CitedMedium="Internet"><Volume>51</Volume><Issue>6</Issue><PubDate><Year>2020</Year><Month>11</Month></PubDate></JournalIssue><Title>Behavior therapy</Title><ISOAbbreviation>Behav Ther</ISOAbbreviation></Journal><ArticleTitle>Effects of Mindfulness-Based Stress Reduction on Psychological Symptoms and Telomere Length: A Randomized Active-Controlled Trial.</ArticleTitle><Pagination><MedlinePgn>984-996</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0005-7894(20)30013-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.beth.2020.01.005</ELocationID><Abstract><AbstractText>Much research has demonstrated the beneficial effects of mindfulness-based stress reduction (MBSR) on psychological and physical health, but it is not known whether MBSR may impact cellular aging in healthy populations. Further, little research has evaluated MBSR against an active control condition, which precludes strong conclusions regarding the unique effects of mindfulness on psychological functioning. The present study examined the effects of MBSR versus music therapy-based stress reduction (MTSR) on trait mindfulness, self-compassion, and several psychological health outcomes, as well as leukocyte telomere length (LTL). One hundred and fifty eight Singaporean Chinese adults were recruited and randomly assigned to an eight-week MBSR or MTSR course. Participants provided blood samples and completed a battery of self-report measures pre- and post-intervention. Analyses showed that participants in the MBSR condition demonstrated significantly greater improvements in depressive symptoms, trait mindfulness, and self-compassion compared to the control condition. Treatment condition did not predict changes in LTL, anxiety, stress, or happiness, though there was a trend for duration of home mindfulness practice to predict increases in LTL. Overall, the study demonstrated MBSR's unique effects in reducing depressive symptoms. Improvements in trait mindfulness and self-compassion correspond with theorized mechanisms of change underlying mindfulness training. The lack of intervention effect with regards to LTL suggests that a more intensive intervention may be required for mindfulness to exert noticeable impact on aging at the cellular level, or that the effect may only emerge over a longer term.</AbstractText><CopyrightInformation>Copyright © 2020. Published by Elsevier Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Keng</LastName><ForeName>Shian-Ling</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Yale-NUS College, Singapore. Electronic address: kengsl@yale-nus.edu.sg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Looi</LastName><ForeName>Pei Shan</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Elysia Li Yan</ForeName><Initials>ELY</Initials><AffiliationInfo><Affiliation>National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yim</LastName><ForeName>Onn-Siong</ForeName><Initials>OS</Initials><AffiliationInfo><Affiliation>National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lai</LastName><ForeName>Poh San</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chew</LastName><ForeName>Soo Hong</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ebstein</LastName><ForeName>Richard P</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>China Center for Behavior Economics and Finance, South Western University of Finance and Economics, China. Electronic address: rpebstein@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Behav Ther</MedlineTA><NlmUniqueID>1251640</NlmUniqueID><ISSNLinking>0005-7894</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001007" MajorTopicYN="N">Anxiety</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001008" MajorTopicYN="Y">Anxiety Disorders</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064866" MajorTopicYN="Y">Mindfulness</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="Y">Stress, Psychological</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016615" MajorTopicYN="Y">Telomere</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">cellular aging</Keyword><Keyword MajorTopicYN="Y">leukocyte telomere length</Keyword><Keyword MajorTopicYN="Y">mindfulness</Keyword><Keyword MajorTopicYN="Y">mindfulness-based stress reduction</Keyword><Keyword MajorTopicYN="Y">psychological symptoms</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>05</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>01</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>14</Day><Hour>8</Hour><Minute>56</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>2</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33051039</ArticleId><ArticleId IdType="pii">S0005-7894(20)30013-7</ArticleId><ArticleId IdType="doi">10.1016/j.beth.2020.01.005</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li><li>Singapour</li></country></list><tree><country name="Singapour"><noRegion><name sortKey="Keng, Shian Ling" sort="Keng, Shian Ling" uniqKey="Keng S" first="Shian-Ling" last="Keng">Shian-Ling Keng</name></noRegion><name sortKey="Chew, Soo Hong" sort="Chew, Soo Hong" uniqKey="Chew S" first="Soo Hong" last="Chew">Soo Hong Chew</name><name sortKey="Lai, Poh San" sort="Lai, Poh San" uniqKey="Lai P" first="Poh San" last="Lai">Poh San Lai</name><name sortKey="Looi, Pei Shan" sort="Looi, Pei Shan" uniqKey="Looi P" first="Pei Shan" last="Looi">Pei Shan Looi</name><name sortKey="Tan, Elysia Li Yan" sort="Tan, Elysia Li Yan" uniqKey="Tan E" first="Elysia Li Yan" last="Tan">Elysia Li Yan Tan</name><name sortKey="Yim, Onn Siong" sort="Yim, Onn Siong" uniqKey="Yim O" first="Onn-Siong" last="Yim">Onn-Siong Yim</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Ebstein, Richard P" sort="Ebstein, Richard P" uniqKey="Ebstein R" first="Richard P" last="Ebstein">Richard P. 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